tert-butyl N-(4-aminobutyl)carbamate → HCID 67272476, 화합물

HRID 251082

반응식

HRID 251082 반응식
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=[C:3]1[CH:11]=O.[C:13]([O:17][C:18](=[O:25])[NH:19][CH2:20][CH2:21][CH2:22][CH2:23][NH2:24])([CH3:16])([CH3:15])[CH3:14].[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>C(Cl)Cl>[C:13]([O:17][C:18](=[O:25])[NH:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24][CH2:11][C:3]1[N:2]([CH3:1])[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[N:4]=1)([CH3:16])([CH3:14])[CH3:15]

참가 물질

5

반응물 3

HCID 4351tert-butyl N-(4-aminobutyl)carbamateHCID 7620841-methyl-1H-1,3-benzodiazole-2-carbaldehydeHCID 5049666Sodium triacetoxyborohydride

생성물 1

HCID 67272476HCID 67272476, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Using General Procedure B, reaction of 1-methyl-1H-benzoimidazole-2-carbaldehyde and (4-amino-butyl)-carbamic acid tert-butyl ester in CH2Cl2 with NaBH(OAc)3 gave {4-[(1-methyl-1H-benzoimidazol-2-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester as a sticky white foam. 1H NMR (CDCl3) δ 1.43 (s, 9H), 1.54-1.64 (m, 4H), 1.80-1.82 (m, 2H), 2.67-2.75 (m, 2H), 3.12-3.13 (m, 2H), 3.82 (s, 3H), 4.06 (s, 2H), 7.23-7.30 (m, 2H), 7.31-7.38 (m, 1H), 7.70-7.76 (m, 1H).

출처 및 근거

ORD 기록
ord-2d402fb1aae84987912e9acc2d2dd017
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863293B2

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