Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → Lys-Val-Lys
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | FMOC-L-valine | HCID 688217 | — |
| 반응물 | Fmoc-Lys(Boc)-OH | HCID 2724628 | — |
| 반응물 | (2S)-2-amino-6-(((tert-butoxy)carbonyl)amino)hexanoic acid | HCID 2733283 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Lys-Val-Lys | HCID 448140 | — |
반응 단계
The protective peptide is built on 1.00 g (0.80 mmol) of H-Lys(Boc)-2-chlorotrityl resin using Fmoc-Val-OH, Fmoc-Lys(Boc)-OH and Palm-OSu. The resin is treated for 30 min with 8 ml of TFA 95% and the solution is instilled in 100 ml of Et2O. The precipitate is sucked off, washed and purified by prep. HPLC after drying. The substance is diluted in 30 ml of dioxan:water=4:6, treated overnight with 2.0 g of BioRad resin (acetate form), filtered, rotated and lyophilized. Yield: 110 mg (0.15 mmol, 19%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07863417B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-73c73a56b2d444b7857252e72f7b484d |
| 출처 메모 | uspto-grants-2011_01 |