Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → Quetiapine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Quetiapine acetate | HCID 11487114 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Quetiapine | HCID 5002 | 98.2% |
반응 단계
The residue of 11-(4-[2-(2-acetyloxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f]-1,4-thiazepine (7.8 g) was dissolved in ethanol (50 ml) and 1M NaOH solution (55 ml) was added. The mixture was stirred at room temperature for 30 min. The product was extracted into toluene (2×100 ml). Evaporation of the toluene phase gave quetiapine base (6.9 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07863441B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-a5210979d7f94179863f210cad5b3ea0 |
| 출처 메모 | uspto-grants-2011_01 |