Piperazine → 1-(5-Nitropyridin-2-yl)piperazine

HRID 251423

반응식

HRID 251423 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[NH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1>O1CCCC1>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[N:3][CH:4]=1)([O-:10])=[O:9]

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 782402-Bromo-5-nitropyridine

생성물 1

HCID 29287991-(5-Nitropyridin-2-yl)piperazine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-Bromo-5-nitropyridine (0.3 g, 1.48 mmol) was treated with piperazine (0.64 g, 7.89 mmol) in tetrahydrofuran (4 ml) and the reaction mixture was stirred for 30 minutes. Subsequently the reaction mixture was poured onto ice-cold water (25 ml) and extracted with ethyl acetate (25 ml). The organic layer was washed with brine and evaporated to furnish the product.

후처리

  1. additionSubsequently the reaction mixture was poured onto ice-cold water (25 ml)
  2. extractionextracted with ethyl acetate (25 ml)
  3. washThe organic layer was washed with brine
  4. customevaporated
  5. customto furnish the product

출처 및 근거

ORD 기록
ord-46396960c5da454bbbfbc49490f48c2d
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863446B2

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