Ethyl Acetate → HCID 22062410, 화합물

HRID 251731

반응식

HRID 251731 반응식
Br[CH2:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=1)=[O:4].[N-:15]=[N+:16]=[N-:17].[Na+].CCOC(C)=O>CC(C)=O>[N:15]([CH2:2][C:3]([C:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH:6]=1)=[O:4])=[N+:16]=[N-:17]

참가 물질

5

반응물 3

HCID 8857Ethyl AcetateHCID 33557Sodium AzideHCID 691792-Bromo-2'-acetonaphthone

생성물 1

HCID 22062410HCID 22062410, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To 2-bromo-1-(2-naphthyl)ethanone in acetone was added NaN3 (1 eq.) and the mixture was stirred at RT for 24 h. EtOAc was added (10 vol.) and the mixture was filtered. The filtrate was concentrated under reduced pressure and the residue was purified by flash chromatography on silica eluting with 10% EtOAc/Petroleum ether to obtain the product as a white solid. 1H NMR (300 MHz, CDCl3) δ: 8.39 (1H, s), 8.02-7.82 (4H, m), 7.69-7.50 (2H, m), 4.68 (2H, s). MS (ES) C12H9N3O requires: 211, found: 212 (M+H)+.

후처리

  1. filtrationthe mixture was filtered
  2. concentrationThe filtrate was concentrated under reduced pressure
  3. customthe residue was purified by flash chromatography on silica eluting with 10% EtOAc/Petroleum ether

출처 및 근거

ORD 기록
ord-d7ccc8a8dc384a5893b3d6b1cf413a82
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07863294B2

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