Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminopyridine → 2-(4-Iodophenyl)imidazo[1,2-a]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminopyridine | HCID 10439 | — |
| 반응물 | 2-Bromo-1-(4-iodophenyl)ethanone | HCID 256572 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(4-Iodophenyl)imidazo[1,2-a]pyridine | HCID 785065 | 82% |
반응 단계
Dissolving 27 g (83 mmol) of crude 2-bromo-4′-iodo acetophenone thus obtained and 8.0 g (85 mmol) of 2-aminopyridine into 200 milliliter of ethanol, adding 10 g of sodium hydrogen carbonate, the resultant suspension was refluxed under heating for 6 hours. After completion of the reaction, separation with filtration was carried out and resultant crystals were washed with water and ethanol, thereby obtaining 21 g of 2-(4-iodophenyl)-imidazo [1,2-a] pyridine (yield: 82%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07867629B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-17ed4fda02294e4a9abd48b72f4472a6 |
| 출처 메모 | uspto-grants-2011_01 |