Acetic Acid → 2,4'-Dibromopropiophenone

HRID 251766

반응식

HRID 251766 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:11])[CH2:9][CH3:10])=[CH:4][CH:3]=1.C(O)(=O)C.[Br:16]Br>O>[Br:16][CH:9]([CH3:10])[C:8]([C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[CH:7][CH:6]=1)=[O:11]

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 24408Bromine2회HCID 66312p-Bromopropiophenone

생성물 1

HCID 6039072,4'-Dibromopropiophenone수율 64%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
10 °C

실험 절차

Dissolving 5.0 g (23 mmol) of 4′-bromopropiophenon into 50 milliliter of acetic acid, and adding 3.7 g (23 mmol) of bromine while cooling with ice, stirred at the temperature of 10° C. for 3 hours. After the color of bromine disappeared, adding water and an extraction was carried out using dichloro-methane. Washing the organic layer with water, it was dried with the use of sodium sulfate. The solvent was removed by distillation and the resultant crystals were washed with hexane thereby obtaining 4.3 g of 2,4′-dibromopropiophenon (yield: 63%).

후처리

  1. temperaturewhile cooling with ice
  2. extractionan extraction
  3. washWashing the organic layer with water, it
  4. dry with materialwas dried with the use of sodium sulfate
  5. customThe solvent was removed by distillation
  6. washthe resultant crystals were washed with hexane

출처 및 근거

ORD 기록
ord-d5e9e381744b4dad9487ebbcb5f6bf1d
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07867629B2

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