2-Aminopyridine → 2-(4'-Bromo-biphenyl-4-yl)-imidazo [1,2-a] pyridine

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반응 단계

Dissolving 6.7 g (19 mmol) of 2-bromo-1-(4′-bromo-biphenyl-4-yl)-ethanone into 50 milliliter of ethanol, adding 2.1 g (22 mmol) of 2-aminopyridine and 5.0 g of sodium hydrogen carbonate, the resultant suspension was refluxed under heating for 7 hours. After completion of the reaction, separation with filtration was carried out and resultant crystals were washed with water and methanol, thereby obtaining yellow crystals of 2-(4′-bromo-biphenyl-4-yl)-imidazo [1,2-a] pyridine in an amount of 5.5 g (yield: 84%).

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