4-Bromophenacyl bromide → 2-(4-Bromo-phenyl)-6-phenyl-imidazo [1,2-a] pyridine

HRID 251778

반응식

HRID 251778 반응식
C1([C:7]2[C:8]([NH2:19])=[N:9][CH:10]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH:12]=2)C=CC=CC=1.Br[CH2:21][C:22]([C:24]1[CH:29]=[CH:28][C:27]([Br:30])=[CH:26][CH:25]=1)=O.C(=O)([O-])O.[Na+]>C(O)C>[Br:30][C:27]1[CH:28]=[CH:29][C:24]([C:22]2[N:19]=[C:8]3[CH:7]=[CH:12][C:11]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)=[CH:10][N:9]3[CH:21]=2)=[CH:25][CH:26]=1

참가 물질

5

반응물 3

HCID 74544-Bromophenacyl bromideHCID 516892Sodium BicarbonateHCID 115723272-Amino-3,5-diphenylpyridine

생성물 1

HCID 230885602-(4-Bromo-phenyl)-6-phenyl-imidazo [1,2-a] pyridine수율 82%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Dissolving crude 3,5-diphenyl-2-amino-pyridine obtained and 5.5 g (20 mmol) of 2,4′-dibromo acetophenone into 80 milliliter of ethanol, adding 3.0 g of sodium hydrogen carbonate, the resultant suspension was refluxed under heating for 7 hours. After completion of the reaction, separation with filtration was carried out and resultant crystals were washed with water and methanol, thereby obtaining 6.9 g of 2-(4-bromo-phenyl)-6-phenyl-imidazo [1,2-a] pyridine (yield: 82%).

후처리

  1. customobtained
  2. temperatureunder heating for 7 hours
  3. customAfter completion of the reaction, separation
  4. filtrationwith filtration
  5. washresultant crystals were washed with water and methanol

출처 및 근거

ORD 기록
ord-5e6630f5c8bf47f0891df99080789d75
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07867629B2

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