Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromophenacyl bromide → 2-(4-Bromo-phenyl)-6-phenyl-imidazo [1,2-a] pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromophenacyl bromide | HCID 7454 | — |
| 반응물 | 5-Phenyl-2-pyridinamine | HCID 105097 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(4-Bromo-phenyl)-6-phenyl-imidazo [1,2-a] pyridine | HCID 23088560 | 49% |
반응 단계
Dissolving crude 5-phenyl-2-amino-pyridine obtained and 8.0 g (29 mmol) of 2,4′-dibromo acetophenone into 100 milliliter of ethanol, adding 3.7 g of sodium hydrogen carbonate, the resultant suspension was refluxed under heating for 3 hours. After completion of the reaction, separation with filtration was carried out and resultant crystals were washed with water and methanol, thereby obtaining 5.4 g of 2-(4-bromo-phenyl)-6-phenyl-imidazo [1,2-a] pyridine (yield: 49%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07867629B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-97b8e143f6d3485a972bd72388bf16a3 |
| 출처 메모 | uspto-grants-2011_01 |