Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Amino-3-chloropyridazine → 3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Amino-3-chloropyridazine | HCID 21643 | — |
| 반응물 | 3-(2-Bromoacetyl)benzonitrile | HCID 2735867 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile | HCID 46835564 | 50% |
반응 단계
1 mmol 3-(2-bromoacetyl)benzonitrile and 1 mmol 6-chloropyridazin-3-amine in 10 ml EtOH were heated to reflux for 12 h, then cooled to room temperature. The orange-red precipitate was collected by filtration, washed with cold EtOH, and air-dried to give the 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile (125 mg, 50%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07868001B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-8b23bb73b09a4ae99af5a05f93b29787 |
| 출처 메모 | uspto-grants-2011_01 |