3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile → 3-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile

HRID 251806노트

반응식

HRID 251806 반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[N:10]=2)[N:7]=1>C1COCC1.CO.[Pd]>[N:10]1[C:9]([C:11]2[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=2)[C:14]#[N:15])=[CH:8][N:6]2[C:5]=1[CH:4]=[CH:3][CH:2]=[N:7]2

참가 물질

4

반응물 1

HCID 468355643-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile

생성물 1

HCID 534394773-(Imidazo[1,2-b]pyridazin-2-yl)benzonitrile

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21899815MeOH tetrahydrofuran용매

실험 절차

2.5 mg 10% Pd-C were added to the solution of 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile (50 mg, 0.2 mmol) in THF/MeOH 25 ml. The reaction mixture was stirred vigorously at room temperature for 4 h under hydrogen and the Pd—C was then removed. The filtrate was concentrated in vacuo to give the 3-(imidazo[1,2-b]pyridazin-2-yl)benzonitrile as a yellow-white solid.

후처리

  1. customthe Pd—C was then removed
  2. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-ab15fbc426654cfabef2405f47f2265e
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07868001B2

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