3-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile → 3-(6-(Methylamino)imidazo[1,2-b]pyridazin-2-yl)benzonitrile

HRID 251812

반응식

HRID 251812 반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[N:10]=2)[N:7]=1.CO.[CH3:21][NH2:22]>>[CH3:21][NH:22][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([CH:8]=[C:9]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[N:10]=2)[N:7]=1

참가 물질

3

반응물 2

HCID 468355643-(6-Chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrileHCID 57454252Monomethylamine methanol

생성물 1

HCID 665874053-(6-(Methylamino)imidazo[1,2-b]pyridazin-2-yl)benzonitrile

반응 조건

온도
125 °C

실험 절차

A mixture of 3-(6-chloroimidazo[1,2-b]pyridazin-2-yl)benzonitrile (0.25 mmol) and 10 mL methylamine methanol solution was heated at 125° C. in microwave synthesizer for 30 min. After purification to provide 3-(6-(methylamino)imidazo[1,2-b]pyridazin-2-yl)benzonitrile.

후처리

  1. customAfter purification

출처 및 근거

ORD 기록
ord-d13bd094e6e94c3e931b6535e20e553c
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07868001B2

연결된 노트

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