Triethylamine → N-(3-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide

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A mixture of N-(3-cyano-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide (0.25 mmol), hydroxylamine hydrochloride (0.75 mmol) and triethylamine (1 mmol) in EtOH (12 mL) was refluxed for 4 hours. After removal of the solvent in vacuo, the residue was dissolved in THF (12 mL), added with (ClCH2CO)2O (0.75 mmol) and triethylamine (1 mmol), and stirred at room temperature for 1 hours. Then it was heated to reflux for another 8 hours. After removal of the solvent in vacuo and addition of water, the mixture was extracted with EtOAc. The combined organic layer was washed with water and brine sequentially, dried over anhydrous Na2SO4 and concentrated. The resulting residue was purified by column chromatography to give N-(3-(5-(chloromethyl)-1,2,4-oxadiazol-3-yl)-5-(imidazo[1,2-b]pyridazin-2-yl)phenyl)methanesulfonamide in 90% yield.

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