Tetrahydrofuran → 3-bromo-N-[4,6-dibromo-2-(N,N'-dimethylhydrazinocarbonyl)phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide

https://huagongshe.com/ko/reaction/252003

참여 물질

역할	이름	HCID	투입량
반응물	Tetrahydrofuran	HCID 8028	—
반응물	1,2-Dimethylhydrazine dihydrochloride	HCID 9380	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	2-[5-bromo-2-(3-chloro-pyridin-2-yl)-2H-pyrazol-3-yl]-6,8-dibromo-benzo[d][1,3]oxazin-4-one	HCID 59200307	—
촉매	Water	HCID 962	—
용매	Water	HCID 962	—
생성물	3-bromo-N-[4,6-dibromo-2-(N,N'-dimethylhydrazinocarbonyl)phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide	HCID 57780381	76.8%

반응 단계

To a mixture of 0.42 g of N,N′-dimethylhydrazine dihydrochloride, five drops of water, 0.87 g of potassium carbonate and 10 ml of tetrahydrofuran was added 0.60 g of 2-[3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazol-5-yl]-6,8-dibromo-4H-3,1-benzoxazine-4-one. The resulting mixture was stirred at room temperature for 19 hours. Water was poured into the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed successively with water and an aqueous saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The resulting residue was subjected to silica gel chromatography to obtain 0.51 g of 3-bromo-N-[4,6-dibromo-2-(N,N′-dimethylhydrazinocarbonyl)phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide of the formula:

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07867949B2
출처 데이터셋	uspto-grants-2011_01
ORD ID	ord-543b30e4a93149fc88c3b5f44572d0fb
출처 메모	uspto-grants-2011_01