Imidazole → 1-{(R)-(4-chlorophenyl) [4-(imidazol-1-ylmethyl)phenyl]methyl}-3-[(3,5-difluorophenyl)(methylsulfonyl)methylene]azetidine

반응식

[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.Cl[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([C@H:14]([C:32]2[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=2)[N:15]2[CH2:18][C:17](=[C:19]([C:24]3[CH:29]=[C:28]([F:30])[CH:27]=[C:26]([F:31])[CH:25]=3)[S:20]([CH3:23])(=[O:22])=[O:21])[CH2:16]2)=[CH:10][CH:9]=1.[I-].[Na+]>ClCCl>[Cl:38][C:35]1[CH:34]=[CH:33][C:32]([C@@H:14]([C:11]2[CH:10]=[CH:9][C:8]([CH2:7][N:1]3[CH:5]=[CH:4][N:3]=[CH:2]3)=[CH:13][CH:12]=2)[N:15]2[CH2:18][C:17](=[C:19]([C:24]3[CH:25]=[C:26]([F:31])[CH:27]=[C:28]([F:30])[CH:29]=3)[S:20]([CH3:23])(=[O:21])=[O:22])[CH2:16]2)=[CH:37][CH:36]=1