Pyridinium chloride → HCID 135741999, 화합물

반응식

S1C2C(O)=CC=CC=2C=N1.[F:11][C:12]1[C:20]2[S:19][N:18]=[CH:17][C:16]=2[C:15]([O:21]C)=[CH:14][CH:13]=1.Cl.N1C=CC=CC=1>>[F:11][C:12]1[CH:13]=[CH:14][C:15]([OH:21])=[C:16]2[C:20]=1[S:19][N:18]=[CH:17]2

참가 물질

반응물 3

HCID 10176127Pyridinium chloride

HCID 19384356Benzo[d]isothiazol-7-ol

HCID 574851307-Fluoro-4-methoxy-1,2-benzothiazole

생성물 1

HCID 135741999HCID 135741999, 화합물수율 65%

실험 절차

A method similar to that described for the synthesis of benzo[d]isothiazol-7-ol in WO 04/043904 was used from 7-fluoro-4-methoxybenzo[d]isothiazole (500 mg, 27.32 mmol) and pyridine hydrochloride (2.5 g, 21.74 mmol) to give the title compound as grey solid (420 mg, 65%).

출처 및 근거

ORD 기록: ord-07a346b76c3547d189fc48bbcb9d8ec3
출처 데이터셋: uspto-grants-2011_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07868017B2

반응 노트

불러오는 중…