Trifluoroacetic acid → 3,4-Dichloro-2-fluorophenol

HRID 252162

반응식

HRID 252162 반응식
FC(F)(F)C(O)=O.[Cl:8][C:9]1[C:10]([F:16])=[C:11]([OH:15])[CH:12]=[CH:13][CH:14]=1.[Cl:17]N1C(=O)CCC1=O>C(#N)C>[Cl:8][C:9]1[C:10]([F:16])=[C:11]([OH:15])[CH:12]=[CH:13][C:14]=1[Cl:17]

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 31398ChlorosuccinimideHCID 27737123-Chloro-2-fluorophenol

생성물 1

HCID 212741443,4-Dichloro-2-fluorophenol수율 48%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Trifluoroacetic acid (0.5 mL) was added to a solution of 3-chloro-2-fluorophenol (750 mg, 5.12 mmol) and N-chlorosuccinimide (684 mg, 5.12 mmol) in acetonitrile (30 mL) and the reaction mixture stirred for 24 h. The mixture was concentrated in vacuo and purified by chromatography on silica gel with heptane:EtOAc (9:1, v/v) as eluent to afford the title compound (440 mg, 48%) as a pale yellow solid.

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. custompurified by chromatography on silica gel with heptane:EtOAc (9:1

출처 및 근거

ORD 기록
ord-2b8967049633402ba141b7d6025c334e
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07868017B2

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