Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → 4-Hydroxy-3-(4-trifluoromethoxy-benzoylamino)-benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 3-Amino-4-hydroxybenzoic acid | HCID 65083 | — |
| 반응물 | 4-(Trifluoromethoxy)benzoyl Chloride | HCID 142110 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-Hydroxy-3-(4-trifluoromethoxy-benzoylamino)-benzoic acid | HCID 60057197 | 57.6% |
반응 단계
To a stirred solution of 3-Amino-4-hydroxy benzoic acid (0.136, 0.00089 mols) and pyridine (0.211 g, 0.00267 mols) in 13 ml dry THF is added 4-trifluoromethoxybenzoyl chloride (0.2 g, 0.00089 mols) and the solution is stirred under nitrogen atmosphere at RT for 10 hrs and then refluxed for 3 hrs. The reaction mixture is rotary evaporated and the residue is slurried in water and filtered to get the amide (0.175 g) which is taken for the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07868033B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-2994cb0e83df417f9862d61358c83ade |
| 출처 메모 | uspto-grants-2011_01 |