Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyridine → HCID 58230872, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-Amino-3-hydroxybenzoic acid | HCID 137566 | — |
| 반응물 | 6-Chloronicotinoyl Chloride | HCID 2782165 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 58230872 | HCID 58230872 | 85.4% |
반응 단계
To a stirred solution of 4-Amino-3-hydroxy benzoic acid (0.490 g, 0.0032 mols) and pyridine (0.76 g, 0.0096 mols) in 50 ml dry THF is added 6-chloronicotinoyl chloride (0.56 g, 0.0032 mols) and the solution is stirred under nitrogen atmosphere at RT for 10 hrs and then refluxed for 3 hrs. The reaction mixture is rotary evaporated and the residue is slurried in water and filtered to get the amide (0.8 g) which is taken for the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07868033B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-ea3d1a1b1e4f451592198345544bf6c8 |
| 출처 메모 | uspto-grants-2011_01 |