Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Bromo-5-fluoropyridine → N-tert-Butyl-4-(5-fluoro-pyridin-3-yl)-3-methyl-benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Bromo-5-fluoropyridine | HCID 820206 | — |
| 반응물 | HCID 178425957 | HCID 178425957 | — |
| 생성물 | N-tert-Butyl-4-(5-fluoro-pyridin-3-yl)-3-methyl-benzenesulfonamide | HCID 66857458 | 56.5% |
반응 단계
This compound was prepared analogous to Example 52, starting from N-tert-butyl-3-methyl-benzenesulfonamide boronic acid (0.5 g, 1.84 mmol) and 5-bromo-3-fluoropyridine (357 mg, 2.03 mmol, 1.1 equiv.) After purification on silica-gel with n-heptane/ethyl acetate, 335 mg of the title compound were obtained as a light yellow solid MS (ES): m/e 321.1 (M−H)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07868030B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-98622a2de9ac482d8e71844938101c23 |
| 출처 메모 | uspto-grants-2011_01 |