Methanol → (4,5-Difluoro-2-nitrophenyl)methanol
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[F:1][C:2]1[CH:3]=[C:4]([C:8]([N+:12]([O-:14])=[O:13])=[CH:9][C:10]=1[F:11])[C:5](O)=[O:6].CO>C1COCC1>[F:11][C:10]1[C:2]([F:1])=[CH:3][C:4]([CH2:5][OH:6])=[C:8]([N+:12]([O-:14])=[O:13])[CH:9]=1참가 물질
4
실험 절차
To a solution of 3,4-difluoro-6-nitrobenzoic acid (3.05 g, 15 mmol) in THF (20 mL) was added BH3 THF (30 mL). The resulting mixture was stirred at room temperature for 2 h and then at 50° C. for 5 h. The resulting mixture was then cooled to room temperature, and methanol (20 mL) was added slowly. The resulting mixture was concentrated, and the residue was treated with methanol twice more, to yield a yellow solid.
후처리
- waitat 50° C. for 5 h
- temperatureThe resulting mixture was then cooled to room temperature
- concentrationThe resulting mixture was concentrated
- additionthe residue was treated with methanol twice more
- customto yield a yellow solid
출처 및 근거
- ORD 기록
- ord-6848fa55f13349e3a09172e81b693666
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07868022B2
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