N-Methyl dicyclohexylamine → 1-{(2E)-3-[4-chloro-3-(trifluoromethyl)phenyl]prop-2-en-1-yl}-1H-indole-2,3-dione

참여 물질

역할	이름	HCID	투입량
반응물	N-Methyl dicyclohexylamine	HCID 24210	—
반응물	4-Bromo-2-chloro-alpha,alpha,alpha-trifluorotoluene	HCID 67959	—
반응물	1-Allylisatin	HCID 1713563	—
촉매	HCID 178418851	HCID 178418851	—
용매	Toluene	HCID 1140	—
생성물	1-{(2E)-3-[4-chloro-3-(trifluoromethyl)phenyl]prop-2-en-1-yl}-1H-indole-2,3-dione	HCID 25006661	—

반응 조건

온도	80 °C

반응 단계

Six separate oven-dried sealed tubes were charged with 1-allyl-1H-indole-2,3-dione (0.100 g, 0.534 mmol), Pd(P(t-Bu)3)2 (0.0082 g, 0.016 mmol), 4-bromo-1-chloro-2-(trifluoro-methyl)benzene (0.139 g, 0.536 mmol), dry toluene (1 mL), and N-cyclohexyl-N-methyl-cyclohexanamine (0.12 mL, 0.57 mmol) under an atmosphere of N2. The tubes were heated for 16 h at 80° C. in an oil bath, and then the reactions were cooled and concentrated in vacuo. The crude material was used in the subsequent step.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07868181B2
출처 데이터셋	uspto-grants-2011_01
ORD ID	ord-c379774113094b519c0163d5660df5b2
출처 메모	uspto-grants-2011_01