Maleic Acid → 4-Amino-N-[2-(4-benzoylpiperidino)ethyl]-N-(3-pyridyl)benzamide maleate

HRID 2527

반응식

HRID 2527 반응식
[NH2:1][C:2]1[CH:32]=[CH:31][C:5]([C:6]([N:8]([CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][CH:20]([C:23](=[O:30])[C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH2:19][CH2:18]2)[C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)=[O:7])=[CH:4][CH:3]=1.[C:33]([OH:40])(=[O:39])/[CH:34]=[CH:35]\[C:36]([OH:38])=[O:37]>C(O)C>[C:33]([OH:40])(=[O:39])/[CH:34]=[CH:35]\[C:36]([OH:38])=[O:37].[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]([CH2:15][CH2:16][N:17]2[CH2:18][CH2:19][CH:20]([C:23](=[O:30])[C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH2:21][CH2:22]2)[C:9]2[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=2)=[O:7])=[CH:31][CH:32]=1

참가 물질

4

반응물 2

HCID 444266Maleic AcidHCID 98888325-HT2A antagonist 1

생성물 1

HCID 676729174-Amino-N-[2-(4-benzoylpiperidino)ethyl]-N-(3-pyridyl)benzamide maleate수율 65%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

4-Amino-N-[2-(4-benzoylpiperidino)ethyl]-N-(3-pyridyl)benzamide (3.00 g, 7.00 mmol) was dissolved in ethanol (10.0 ml) to which was subsequently added a ethanol solution (20.0 ml) of maleic acid (812.0 mg, 7.00 mmol) at room temperature, and then stirred. After the solvent was removed by evaporation, the thus precipitated crystals were collected by filtration and washed with ether, and then purified by recrystallization from ethanol-water mixed solution to obtain 2.476 g (65%) of the title compound in a colorless powder form.

후처리

  1. customAfter the solvent was removed by evaporation
  2. filtrationthe thus precipitated crystals were collected by filtration
  3. washwashed with ether
  4. custompurified by recrystallization from ethanol-water mixed solution

출처 및 근거

ORD 기록
ord-5dbd58a197604caab9440bf88042ff6e
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05728835

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