Nitric Acid → 2-Bromo-1,3-dimethyl-4-nitrobenzene
반응식
[N+:1]([O-:4])(O)=[O:2].[Br:5][C:6]1[C:11]([CH3:12])=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:13]>C(O)(=O)C>[CH3:13][C:7]1[C:8]([N+:1]([O-:4])=[O:2])=[CH:9][CH:10]=[C:11]([CH3:12])[C:6]=1[Br:5]참가 물질
4
실험 절차
Fuming nitric acid (>90% yellow fuming HNO3) is slowly added to a solution of 2-bromo-m-xylene (20 g, 150 mmol) in acetic acid (100 ml) cooled in an ice bath (above freezing point). The resulting mixture is allowed to warm to room temperature, stirred for 1 hour, and heated at 80° C. for 2 hours or until the reaction is shown to be complete by GC/MS analysis following micro-scale base work-up. The reaction mixture is cooled to room temperature and poured into ice/water with stirring. The resulting yellow precipitates are collected by suction filtration and air dried to obtain 2,6-dimethyl-3-nitrobromobenzene.
후처리
- temperaturecooled in an ice bath (above freezing point)
- temperatureheated at 80° C. for 2 hours or until the reaction
- temperatureThe reaction mixture is cooled to room temperature
- stirringwith stirring
- customThe resulting yellow precipitates
- filtrationare collected by suction filtration and air
- customdried
출처 및 근거
- ORD 기록
- ord-be524cb8b1a6445599b71a2c69566762
- 출처 데이터셋
- uspto-grants-2005_02
- 특허 번호
- US06858637B2
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