Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 1-Methyl-1H-indole-6-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methyl N-methylindole-6-carboxylate | HCID 639843 | — |
| 용매 | Methanol tetrahydrofuran water | HCID 21892291 | — |
| 생성물 | 1-Methyl-1H-indole-6-carboxylic acid | HCID 19819261 | 248.6% |
반응 단계
Methyl 1-methyl-1H-indole-6-carboxylate 166 (1.24 mmol) was stirred with sodium hydroxide (0.59 g, 14.88 mmol) in a 2:2:1 mixture of methanol/THF/water (7.5 mL) for 36 hrs at rt to form a precipitate which was collected by filtration and lyophilized overnight to give the title compound 167 (0.54 g, 99% yield). MS: 175.06 (calc), 176.1 (obs).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07868205B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-5902ff32a3db45d1bd8d0c87b9ee4246 |
| 출처 메모 | uspto-grants-2011_01 |