Morpholine → 2-Methyl-4-chloro-6-morpholino-pyridine

HRID 252983노트

반응식

HRID 252983 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4](Cl)[N:3]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>ClCCl>[CH3:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[N:3]=1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 119590832,4-Dichloro-6-methylpyridine

생성물 1

HCID 575505222-Methyl-4-chloro-6-morpholino-pyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
-78 °C

실험 절차

2-Methyl-4,6-dichloropyridine (256 mmol) is dissolved in dichloromethane (200 mL) and chilled to −78° C. in an inert atmosphere. Morpholine (550 mol) dissolved in dichloromethane (100 mL) is added slowly. The reaction is allowed to warm to room temperature while stirring overnight. The organic layer is washed with saturated ammonium chloride (2×100 mL), dried with sodium sulfate, and evaporated to give 2-methyl-4-chloro-6-morpholino-pyridine.

후처리

  1. additionis added slowly
  2. temperatureto warm to room temperature
  3. washThe organic layer is washed with saturated ammonium chloride (2×100 mL)
  4. dry with materialdried with sodium sulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-f6527866ffd046748a51042fcc0e358d
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07872005B2

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