HCID 86631214, 화합물 → HCID 86631215, 화합물

HRID 253017

반응식

HRID 253017 반응식
C=[C:2]([CH2:26][CH2:27][CH3:28])[CH2:3][CH2:4][N:5]([C@@H:18]([CH2:23][CH:24]=C)[C:19]([O:21][CH3:22])=[O:20])[S:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N+:15]([O-:17])=[O:16])(=[O:8])=[O:7]>C(Cl)Cl.CC1C=C(C)C(N2C(=[Ru](Cl)(Cl)=CC3C=CC=CC=3)N(C3C(C)=CC(C)=CC=3C)CC2)=C(C)C=1.C1CCC(P(C2CCCCC2)C2CCCCC2)CC1>[N+:15]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[S:6]([N:5]1[CH2:4][CH2:3][C:2]([CH2:26][CH2:27][CH3:28])=[CH:24][CH2:23][C@H:18]1[C:19]([O:21][CH3:22])=[O:20])(=[O:8])=[O:7])([O-:17])=[O:16]

참가 물질

4

반응물 1

HCID 86631214HCID 86631214, 화합물

생성물 1

HCID 86631215HCID 86631215, 화합물수율 82%

시약·촉매·용매 2

HCID 11147261(1,3-Dimesitylimidazolidin-2-ylidene)(tricyclohexylphosphine)benzylidene ruthenium dichloride촉매HCID 6344Dichloromethane용매

실험 절차

Benzylidene[1,3-bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(tricyclohexylphosphine)ruthenium (250 mg, 0.295 mmol) was added to a solution of 2.42 g (5.89 mmol) of the title compound produced in step (iii) of Example 47 in methylene chloride (295 ml), and the mixture was heated under reflux for one hr. The reaction solution was cooled to room temperature, and the solvent was removed under the reduced pressure. The residue was purified by column chromatography on silica gel (hexane:ethyl acetate=10:1) to give 1.84 g (yield 82%) of the title compound.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for one hr
  3. customthe solvent was removed under the reduced pressure
  4. customThe residue was purified by column chromatography on silica gel (hexane:ethyl acetate=10:1)

출처 및 근거

ORD 기록
ord-0e8c165c80d44013a534d4718e2784c2
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07871982B2

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