Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → Cyclopentyl-1-cyclopentyl-6-oxo-1,6-dihydropyridazine-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Iodocyclopentane | HCID 73784 | — |
| 반응물 | 6-Hydroxypyridazine-3-carboxylic Acid | HCID 305970 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Cyclopentyl-1-cyclopentyl-6-oxo-1,6-dihydropyridazine-3-carboxylate | HCID 66845103 | — |
반응 단계
6-Oxo-1,6-dihydropyridazine-3-carboxylic acid (1 g, 7.14 mmol) was stirred with cyclopentyl iodide (2.05 ml, 17.8 mmol) and potassium carbonate (3 g, 21.4 mmol) in 15 ml DMF for 14 h at room temperature. 50 ml CH2Cl2 was added and the reaction mixture was filtered. The filtrate was concentrated and the title compound was purified by prep HPLC. Yield: 20 mg (0.072 mmol, 1%, MS m/z: 277(100%, M+1)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07872009B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-c6df35c495594acebc47d27daaec753d |
| 출처 메모 | uspto-grants-2011_01 |