참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chloroacetic Acid | HCID 300 | — |
| 반응물 | N-Methyl-o-phenylenediamine | HCID 78498 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Sodium Bicarbonate | HCID 516892 | — |
| 생성물 | 2-(Chloromethyl)-1-methylbenzimidazole | HCID 248044 | 87.8% |
반응 단계
N-methyl-phenylenediamine (1 g, 8.2 mmol) and chloroacetic acid (0.9 g, 9.4 mol) were dissolved in 5 N aqueous hydrochloric acid (10 mL) and stirred at 55° C. overnight. The reaction mixture was then diluted with water and basified with solid sodium bicarbonate to give a precipitate which was filtered, washed with water and dried to provide the desired compound (1.3 g, 87%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07872018B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_01 |
|---|
| ORD ID | ord-ba330bcfa33e419daff6496203bb19c7 |
|---|
| 출처 메모 | uspto-grants-2011_01 |
|---|
