Ethanol → 5-Amino-1-(2-chloro-6-ethoxy-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole

참여 물질

역할	이름	HCID	투입량
반응물	Ethanol	HCID 702	—
반응물	Fipronil sulfide	HCID 9953940	—
반응물	Ethylacetate heptane	HCID 21899848	—
반응물	Sodium t-butoxide	HCID 23676156	—
촉매	copper(I) bromide	HCID 24593	—
용매	Water	HCID 962	—
용매	Dimethylformamide	HCID 6228	—
생성물	5-Amino-1-(2-chloro-6-ethoxy-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole	HCID 11419008	—

반응 조건

온도	90 °C

반응 단계

To a mixture of 5-amino-1-(2,6-dichloro-4-trifluoromethylphenyl)-3-cyano-4-trifluoromethylthiopyrazole (4.5 g, 10.7 mmol) and ethanol (0.73 g, 16.0 mmol) in N,N-dimethylformamide (25 ml), was added sodium tert-butoxide (1.54 g, 16.0 mmol) and copper(I)bromide (0.08 g, 0.5 mmol). The mixture was heated at 90° C. for 7 hours under nitrogen. After extractive workup (heptane-ethyl acetate, water) and column chromatography the title product was obtained (2.17 g), mp 166° C., 1H-NMR: 1.34 (3H), 4.14 (2H), 4.35 (2H), 7.20 and 7.45; 19F-NMR: −45.2, −63.9.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07872038B2
출처 데이터셋	uspto-grants-2011_01
ORD ID	ord-25d93cffb5214c8f898fd5d5e569c14d
출처 메모	uspto-grants-2011_01