3-Fluorobenzenesulfonyl Chloride → 3-fluoro-N-(3-iodo-1H-indazol-5-yl)benzenesulfonamide

HRID 25370

반응식

HRID 25370 반응식
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[C:5]2[I:11].[F:12][C:13]1[CH:14]=[C:15]([S:19](Cl)(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1>N1C=CC=CC=1>[F:12][C:13]1[CH:14]=[C:15]([S:19]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][N:6]=[C:5]3[I:11])(=[O:21])=[O:20])[CH:16]=[CH:17][CH:18]=1

참가 물질

4

반응물 2

HCID 27342583-Fluorobenzenesulfonyl ChlorideHCID 178507363HCID 178507363, 화합물

생성물 1

HCID 1785274633-fluoro-N-(3-iodo-1H-indazol-5-yl)benzenesulfonamide수율 10.8%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

3-Fluoro-N-(3-iodo-1H-indazol-5-yl)benzenesulfonamide can be obtained as described in Example 2 from 230 mg of 5-amino-3-iodo-1H-indazole, 5 ml of pyridine and 173 mg of 3-fluorobenzenesulfonyl chloride. 40 mg of 3-fluoro-N-(3-iodo-1H-indazol-5-yl)benzenesulfonamide are thus obtained in the form of a cream solid melting at 189° C.

출처 및 근거

ORD 기록
ord-601f59a7f2504c518122b659c0f975ac
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858638B2

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