Ammonia → HCID 178507363, 화합물

HRID 25371

반응식

HRID 25371 반응식
[I:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([N+:11]([O-])=O)[CH:9]=2)[NH:4][N:3]=1.C(O)C.O.N>C(OCC)(=O)C.ClCCl>[NH2:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][N:3]=[C:2]2[I:1]

참가 물질

6

반응물 4

HCID 222AmmoniaHCID 702EthanolHCID 962WaterHCID 178526495HCID 178526495, 화합물

생성물 1

HCID 178507363HCID 178507363, 화합물수율 25.7%

시약·촉매·용매 1

HCID 21226138Dichloromethane ethylacetate용매

실험 절차

5-Amino-3-iodo-1H-indazole can be obtained as described in Example 4 from 1 g of 3-iodo-5-nitro-1H-indazole, 20 ml of ethanol, 6.9 g of ferrous sulfate, 10.8 ml of distilled water and 8.2 ml of 32% aqueous ammonia. 230 mg of 5-amino-3-iodo-1H-indazole are thus obtained in the form of a yellow foam (Rf=0.12, silica gel thin layer chromatography, eluent: ethyl acetate/dichloromethane (2/8 by volume)).

출처 및 근거

ORD 기록
ord-99a073bb0a594f1b8fbc672a6e56d23e
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858638B2

연결된 노트

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