Potassium Nitrate → HCID 57827875, 화합물

HRID 253716

반응식

HRID 253716 반응식
[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[N:4][CH:3]=1.[N+:12]([O-])([O-:14])=[O:13].[K+]>S(=O)(=O)(O)O>[F:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[N+:12]([O-:14])=[O:13])[CH:5]=[N:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24434Potassium NitrateHCID 6409734-Fluoroisoquinoline

생성물 1

HCID 57827875HCID 57827875, 화합물

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

Specifically, 4-fluoroisoquinoline (3) is nitrified with potassium nitrate in sulfuric acid, to thereby form 4-fluoro-5-nitroisoquinoline (4a) and a position isomer (4b) thereof [step A]. Subsequently, these two products are reduced by use of concentrated hydrochloric acid and stannous chloride dihydrate, to thereby form 4-fluoro-5-aminoisoquinoline (5a) and a position isomer (5b) thereof [step B]. 5-Amino-4-fluoroisoquinoline (5a) is separated through column chromatography for purification [step C]. The purified product is diazotized with sodium nitrite [step D]. The diazo compound is subjected to Sandmeyer reaction employing SO2 gas-saturated acetic acid and cupric chloride dihydrate [step E], to thereby yield 4-fluoroisoquinoline-5-sulfonyl chloride (2a).

출처 및 근거

ORD 기록
ord-320f6e4891724c1588cfbf934bd25e3a
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07872136B2

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