n-Cyclopentylcyclohexanamine → [5-(3-Cyclohexyl-3-cyclopentyl-ureido)-[1,3,4]thiadiazol-2-ylsulfanyl]-acetic acid

HRID 253773

반응식

HRID 253773 반응식
C([O:3][C:4](=[O:27])[CH2:5][S:6][C:7]1[S:8][C:9]([NH:12][C:13]([N:15]([CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)[CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:14])=[N:10][N:11]=1)C.C1(NC2CCCC2)CCCCC1.C(OC(=O)CSC1SC(N)=NN=1)C>>[CH:21]1([N:15]([CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[C:13](=[O:14])[NH:12][C:9]2[S:8][C:7]([S:6][CH2:5][C:4]([OH:27])=[O:3])=[N:11][N:10]=2)[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]1

참가 물질

4

반응물 3

HCID 219797n-CyclopentylcyclohexanamineHCID 351912Ethyl 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetateHCID 66872747[5-(3-Cyclohexyl-3-cyclopentyl-ureido)-[1,3,4]thiadiazol-2-ylsulfanyl]-acetic acid ethyl ester

생성물 1

HCID 57883528[5-(3-Cyclohexyl-3-cyclopentyl-ureido)-[1,3,4]thiadiazol-2-ylsulfanyl]-acetic acid

실험 절차

[5-(3-Cyclohexyl-3-cyclopentyl-ureido)-[1,3,4]thiadiazol-2-ylsulfanyl]-acetic acid ethyl ester prepared as described in general procedures (A) and (B) using cyclohexyl-cyclopentyl-amine and ethyl-2-[5-amino-1,3,4-thiadiazol-2-yl-thio]acetate. Hydrolysis using general procedure (F) gave the title compound.

후처리

  1. customHydrolysis

출처 및 근거

ORD 기록
ord-228ef38c535443fe9a4cda920493068b
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07872139B2

연결된 노트

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