2-Methanesulfonylbenzene-1-sulfonyl chloride → N-phenyl-5-(2-methylsulfonylbenzenesulfonylamino)-1H-indazole-3-carboxamide

HRID 25380

반응식

HRID 25380 반응식
[C:1]1([NH:7][C:8]([C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH2:19])[CH:17]=3)[NH:12][N:11]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:20][S:21]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=1[S:30](Cl)(=[O:32])=[O:31])(=[O:23])=[O:22]>N1C=CC=CC=1>[C:1]1([NH:7][C:8]([C:10]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH:19][S:30]([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4[S:21]([CH3:20])(=[O:23])=[O:22])(=[O:32])=[O:31])[CH:17]=3)[NH:12][N:11]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 27351782-Methanesulfonylbenzene-1-sulfonyl chlorideHCID 10243915N-phenyl-5-amino-1H-indazole-3-carboxamide

생성물 1

HCID 10479841N-phenyl-5-(2-methylsulfonylbenzenesulfonylamino)-1H-indazole-3-carboxamide수율 67.7%

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

N-Phenyl-5-(2-methylsulfonylbenzenesulfonylamino)-1H-indazole-3-carboxamide can be obtained as described in Example 2 from 40 mg of N-phenyl-5-amino-1H-indazole-3-carboxamide, 4 ml of pyridine and 40 mg of 2-methylsulfonylbenzenesulfonyl chloride. 50 mg of N-phenyl-5-(2-methylsulfonylbenzenesulfonylamino)-1H-indazole-3-carboxamide are thus obtained in the form of a pale yellow solid melting at 258° C. (analysis C21H18N4O5S2.0.48H2O, % calculated C, 53.61; H, 3.86; N, 11.91; O, 17.00; S, 13.63. % found C, 53.17; H, 3.48; N, 11.58; S, 14.08).

출처 및 근거

ORD 기록
ord-b6b0a2cdab4b46e28c696798c69ed297
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858638B2

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