Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(Piperazin-1-yl)propan-1-one → 1,1-Dicyclohexyl-3-[5-(4-propionyl-piperazin-1-ylmethyl)-thiazol-2-yl]-urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(Piperazin-1-yl)propan-1-one | HCID 3844375 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 1,1-Dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea | HCID 57883471 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 1,1-Dicyclohexyl-3-[5-(4-propionyl-piperazin-1-ylmethyl)-thiazol-2-yl]-urea | HCID 57883729 | 15% |
반응 단계
Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (60 mg, 0.18 mmol), 1-piperazinyl-1-propanone (39 mg, 0.22 mmol), catalytic acetic acid and sodium triacetoxyborohydride (47 mg, 0.22 mmol) to afford 12 mg (15%) of the desired product after purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07872139B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-60825e8aca8f4cc3844cc522b2802726 |
| 출처 메모 | uspto-grants-2011_01 |