HCID 61776502, 화합물 → HCID 11773524, 화합물

HRID 253885노트

반응식

HRID 253885 반응식
C([O:3][C:4](=[O:27])[CH2:5][S:6][C:7]1[S:11][C:10]([NH:12][C:13]([N:15]([CH:20]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[CH:16]2[CH2:19][CH2:18][CH2:17]2)=[O:14])=[N:9][CH:8]=1)C.C1(NC2CCC2)CCCCCC1.NC1SC=NC=1.C(OC(=O)CS)C>>[CH:16]1([N:15]([CH:20]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)[C:13](=[O:14])[NH:12][C:10]2[S:11][C:7]([S:6][CH2:5][C:4]([OH:27])=[O:3])=[CH:8][N:9]=2)[CH2:17][CH2:18][CH2:19]1

참가 물질

4

반응물 3

HCID 61776502HCID 61776502, 화합물HCID 866111945-Aminothiazole 2-mercaptoacetic acid ethyl esterHCID 86611209HCID 86611209, 화합물

생성물 1

HCID 11773524HCID 11773524, 화합물

실험 절차

[2-(3-Cycloheptyl-3-cyclobutyl-ureido)-thiazol-5-ylsulfanyl]-acetic acid ethyl ester prepared as described in general procedures (A) and (B) using cycloheptyl-cyclobutylamine and 5-aminothiazole-2-mercaptoacetic acid ethyl ester. Hydrolysis using general procedure (F) gave the title compound.

후처리

  1. customHydrolysis

출처 및 근거

ORD 기록
ord-c7bb1acea5264c20936a6df1887a964a
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07872139B2

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