Ammonia → 5-amino-3-methylsulfonylamino-1H-indazole

HRID 25391노트

반응식

HRID 25391 반응식
[CH3:1][S:2]([NH:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([N+:15]([O-])=O)[CH:13]=2)[NH:8][N:7]=1)(=[O:4])=[O:3].C(O)C.N>O>[NH2:15][C:12]1[CH:13]=[C:14]2[C:9](=[CH:10][CH:11]=1)[NH:8][N:7]=[C:6]2[NH:5][S:2]([CH3:1])(=[O:4])=[O:3]

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 702EthanolHCID 225672013-methylsulfonylamino-5-nitro-1H-indazole

생성물 1

HCID 225672845-amino-3-methylsulfonylamino-1H-indazole수율 44.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

5-Amino-3-methylsulfonylamino-1H-indazole can be obtained as described in Example 4 from 256 mg of 3-methylsulfonylamino-5-nitro-1H-indazole, 10 ml of ethanol, 2 g of ferrous sulfate, 3.2 ml of water and 2.4 ml of 32% aqueous ammonia. 0.1 g of 5-amino-3-methylsulfonylamino-1H-indazole is thus obtained in the form of an oil used as it is in the following step.

출처 및 근거

ORD 기록
ord-2e6334424ebd4780a11212be5bfd5fb5
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858638B2

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