Bromine → 2-bromo-8,9-dihydro-4H-cyclopenta[def]phenanthrene

HRID 254128

반응식

HRID 254128 반응식
[CH:1]1[C:14]2[CH2:13][CH2:12][C:11]3[CH:10]=[CH:9][CH:8]=[C:7]4[CH2:15][C:4]([C:5]=2[C:6]=34)=[CH:3][CH:2]=1.[Br:16]Br>C(Cl)(Cl)(Cl)Cl>[Br:16][C:2]1[CH:3]=[C:4]2[CH2:15][C:7]3[C:6]4[C:5]2=[C:14]([CH2:13][CH2:12][C:11]=4[CH:10]=[CH:9][CH:8]=3)[CH:1]=1

참가 물질

4

반응물 2

HCID 24408BromineHCID 6057498,9-Dihydrocyclopenta[def]phenanthrene

생성물 1

HCID 125243632-bromo-8,9-dihydro-4H-cyclopenta[def]phenanthrene수율 83.3%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

반응 조건

온도
0 °C

실험 절차

8,9-dihydro-4H-cyclopenta[def]phenanthrene (4.0 g, 20.8 mmol) was put into a 250 ml round bottom flask (RBF), and CCl4 (100 ml) was added thereto. The reaction mixture was cooled to 0° C., and Br2 (3.3 g, 20.8 mmol) was dropwise added thereto. The reaction solution was incubated for 4 hours and a 10% NaSO3 solution was added thereto. The organic phase was separated, concentrated under a reduced pressure, and recrystallized from n-hexane to obtain 4.7 g of a 2-bromo-8,9-dihydro-4H-cyclopenta[def]phenanthrene compound.

후처리

  1. customThe organic phase was separated
  2. concentrationconcentrated under a reduced pressure
  3. customrecrystallized from n-hexane

출처 및 근거

ORD 기록
ord-59c6361377d046c5afbbdd3118e3e552
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875367B2

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