Acetonitrile → 4-Pyrimidinecarbonitrile,2-amino-6-(2-furanyl)-5-methyl-

HRID 254169

반응식

HRID 254169 반응식
Cl[C:2]1[C:7]([CH3:8])=[C:6]([C:9]2[O:10][CH:11]=[CH:12][CH:13]=2)[N:5]=[C:4]([NH2:14])[N:3]=1.[C:15](#[N:17])C>>[NH2:14][C:4]1[N:3]=[C:2]([C:15]#[N:17])[C:7]([CH3:8])=[C:6]([C:9]2[O:10][CH:11]=[CH:12][CH:13]=2)[N:5]=1

참가 물질

3

반응물 2

HCID 6342AcetonitrileHCID 185072434-Chloro-6-(2-furyl)-5-methylpyrimidine-2-amine

생성물 1

HCID 668471164-Pyrimidinecarbonitrile,2-amino-6-(2-furanyl)-5-methyl-수율 65%

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온도
140 °C

실험 절차

A solution of 4-chloro-6-(2-furyl)-5-methylpyrimidine-2-amine (80 mg, 0.38 mmol) in acetonitrile (4 mL) was treated with polymer supported cyamide (0.636 mg, 1.91 mmol), stirred at 140° C. in the microwave for 30 min, filtered to remove the resin and the filter cake washed with acetonitrile. The filtrate was concentrated in vacuo to give the title compound (50 mg, 65%) as off-white solid; NMR δH (400 MHz, DMSO) 2.48 (3H, s), 6.75 (1H, dd, J 1.7, 3.5 Hz), 7.04 (2H br s), 7.28 (1H, dd, J 0.7, 3.5 Hz) and 8.00 (1H, dd, J 0.7, 1.7 Hz); M/Z 201 (M=H)+; HPLC 1.1 min. (50/80).

후처리

  1. filtrationfiltered
  2. customto remove the resin
  3. washthe filter cake washed with acetonitrile
  4. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-c74d9c1988604ab2acf5b2d783e0e5bb
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875600B2

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