Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Bicarbonate → n-(3-Benzo[b]thiophen-3-yl-1h-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | (1-Benzothiophen-3-yl)boronic acid | HCID 2776344 | — |
| 반응물 | Tert-butyl 3-iodo-5-(2-methylsulfonylbenzenesulfonylamino)indazole-1-carboxylate | HCID 22567134 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | n-(3-Benzo[b]thiophen-3-yl-1h-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide | HCID 22567210 | 35.8% |
반응 단계
N-(3-Benzo[b]thiophen-3-yl-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide can be obtained as described in Example 59 from 0.5 g of tert-butyl 3-iodo-5-(2-methylsulfonylbenzenesulfonylamino)indazole-1-carboxylate, 300 mg thianaphthene-3-boronic acid, 20 ml of dimethylformamide, 1.9 ml of saturated aqueous solution of sodium hydrogencarbonate and 25 mg of tetrakis(triphenylphosphine)palladium[0]. 150 mg of N-(3-benzo[b]thiophen-3-yl-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide are thus obtained in the form of a white solid melting at 235° C. (analysis C22H17N3O4S3 % calculated C, 54.64; H, 3.54; N, 8.69; O, 13.23; S, 19.89. % found C, 54.35; H, 3.68; N, 8.68; S, 20.12).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06858638B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-c61977695e40462abcbd63c0f50a69b3 |
| 출처 메모 | uspto-grants-2005_02 |