Potassium Carbonate → HCID 42629230, 화합물

HRID 254296

반응식

HRID 254296 반응식
Br[C:2]1[N:6]2[C:7]3[C:12]([N:13]=[C:14]([CH3:15])[C:5]2=[C:4]([CH3:17])[N:3]=1)=[CH:11][CH:10]=[C:9]([F:16])[CH:8]=3.[Cl:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[C:23]([Cl:25])[CH:24]=1.C([O-])([O-])=O.[K+].[K+]>C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[Cl:18][C:19]1[CH:20]=[C:21]([C:2]2[N:6]3[C:7]4[C:12]([N:13]=[C:14]([CH3:15])[C:5]3=[C:4]([CH3:17])[N:3]=2)=[CH:11][CH:10]=[C:9]([F:16])[CH:8]=4)[CH:22]=[C:23]([Cl:25])[CH:24]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 27343313,5-Dichlorophenylboronic acidHCID 577324521-Bromo-8-fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline

생성물 1

HCID 42629230HCID 42629230, 화합물수율 78%

시약·촉매·용매 1

HCID 178418397HCID 178418397, 화합물촉매

실험 절차

Following the general Suzuki coupling procedure, reaction of bromide 5A (75 mg, 0.25 mmol), 3,5-dichlorophenylboronic acid (58 mg, 0.30 mmol), K2CO3 (105 mg, 0.75 mmol) and Pd(PPh3)4 (5.8 mg, 0.005 mmol) provided the coupling product as a white powder (70 mg, 78% yield). EIMS 360.0 [M+H]+.

출처 및 근거

ORD 기록
ord-87425095fd3243bf8895ea79040d8ade
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875618B2

연결된 노트

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