Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1-(2,4-Difluorophenyl)-8-fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2,4-Difluorophenylboronic acid | HCID 2734334 | — |
| 반응물 | 1-Bromo-8-fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline | HCID 57732452 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 생성물 | 1-(2,4-Difluorophenyl)-8-fluoro-3,4-dimethylimidazo[1,5-a]quinoxaline | HCID 42629232 | 50.1% |
반응 단계
Following the general Suzuki coupling procedure, reaction of bromide 5A (75 mg, 0.25 mmol), 2,4-difluorophenylboronic acid (48 mg, 0.30 mmol), K2CO3 (105 mg, 0.75 mmol) and Pd(PPh3)4 (5.8 mg, 0.005 mmol) provided the coupling product as a white powder (41 mg, 50% yield). EIMS 328.0 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07875618B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-c5428db5ffa14cbd914021a161fcebfb |
| 출처 메모 | uspto-grants-2011_01 |