Nitric Acid → HCID 14473250, 화합물

HRID 254325노트

반응식

HRID 254325 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][C:9]([F:12])([F:11])[F:10])[CH:3]=1.S(=O)(=O)(O)O.[N+:18]([O-])([OH:20])=[O:19]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:18]([O-:20])=[O:19])=[C:4]([O:8][C:9]([F:10])([F:11])[F:12])[CH:3]=1

참가 물질

4

반응물 3

HCID 944Nitric AcidHCID 1118Sulfuric Acid2회HCID 27772861-Fluoro-3-(trifluoromethoxy)benzene

생성물 1

HCID 14473250HCID 14473250, 화합물

실험 절차

To 1-fluoro-3-trifluoromethoxybenzene (1 mL) was added concentrated sulfuric acid (1 mL) at 0° C. To the cold solution was added dropwise (0.7 mL) of a solution made from concentrated nitric acid (1 mL) and concentrated sulfuric acid (1 mL). The reaction was slowly allowed to warm to room temperature then poured onto ice and extracted with ether. The organic layer was separated and washed with sodium hydroxide 1N, then brined and dried over magnesium sulfate. The solvent was removed under reduce pressure at room temperature. A pale yellow oil (1 g) was recovered and used without further purification.

후처리

  1. additionthen poured onto ice
  2. extractionextracted with ether
  3. customThe organic layer was separated
  4. washwashed with sodium hydroxide 1N
  5. dry with materialdried over magnesium sulfate
  6. customThe solvent was removed
  7. customat room temperature
  8. customA pale yellow oil (1 g) was recovered
  9. customused without further purification

출처 및 근거

ORD 기록
ord-ec1bb395d60b45e989a6646a36bd8ca7
출처 데이터셋
uspto-grants-2011_01
특허 번호
US07875618B2

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