Ethyl 2,4-dioxo-1-(piperidin-1-yl)piperidine-3-carboxylate → [1,1']Bipiperidinyl-2,4-dione

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The oil from step 3 was dissolved in 10% acetic acid (250 ml) and the solution boiled under reflux for one hour. The cooled reaction mixture was evaporated, and the residue purified by flash chromatography (CH2Cl2: acetone 9:1-1:1) to give 4.00 g (36%) of the title compound as a semi-solid.

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