Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 254341생성일: 2026년 10월 24일
Benzenamine, 2-chloro-4-fluoro- → 4-[(2-chloro-4-fluorophenyl)amino]-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one
https://huagongshe.com/ko/reaction/254341
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzenamine, 2-chloro-4-fluoro- | HCID 75013 | — |
| 반응물 | [1,1']Bipiperidinyl-2,4-dione | HCID 22038474 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-[(2-chloro-4-fluorophenyl)amino]-1-piperidin-1-yl-5,6-dihydropyridin-2(1H)-one | HCID 66866669 | 55% |
반응 단계
[1,1′]-Bipiperidinyl-2,4-dione (2.00 g, 10.19 mmol) was dissolved in toluene (8 ml) and 2-chloro-4-fluorophenylamine (1.78 g, 12.23 mmol) was added. More toluene (5 ml) was added. The reaction mixture was boiled under reflux at 110° C. for 17 h then allowed to cool. When the reaction mixture reached rt the product precipitated and it was collected by filtration to yield a beige solid (1.80 g, 55%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07875626B2 |
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| 출처 데이터셋 | uspto-grants-2011_01 |
|---|
| ORD ID | ord-351039c1318f482094b1d994f98819e2 |
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| 출처 메모 | uspto-grants-2011_01 |
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