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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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{4-[4-(3-tert-Butoxycarbonylamino-3-carbamoylpropoxy)phenyl]butyl}carbamic acid benzyl ester → {3-[4-(4-Aminobutyl)phenoxy]-1-carbamoylpropyl}carbamic acid tert-butyl ester

HRID 254362
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인쇄 미리보기

반응식

HRID 254362 반응식
C(OC(=O)[NH:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][CH2:23][CH:24]([NH:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[C:25](=[O:27])[NH2:26])=[CH:17][CH:16]=1)C1C=CC=CC=1>[OH-].[OH-].[Pd+2].CO.ClCCl>[C:32]([O:31][C:29](=[O:30])[NH:28][CH:24]([C:25](=[O:27])[NH2:26])[CH2:23][CH2:22][O:21][C:18]1[CH:17]=[CH:16][C:15]([CH2:14][CH2:13][CH2:12][CH2:11][NH2:10])=[CH:20][CH:19]=1)([CH3:35])([CH3:33])[CH3:34]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 1

HCID 59750592{4-[4-(3-tert-Butoxycarbonylamino-3-carbamoylpropoxy)phenyl]butyl}carbamic acid benzyl ester

생성물 1

HCID 66849495{3-[4-(4-Aminobutyl)phenoxy]-1-carbamoylpropyl}carbamic acid tert-butyl ester

시약·촉매·용매 3

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매HCID 6344Dichloromethane용매

실험 절차

A mixture of N-Cbz amide 110 (436 mg, 0.873 mmol) and Pearlman's catalyst (100 mg) in methanol (10 mL) and dichloromethane (10 mL) was stirred under atmospheric hydrogen for 18 h. Catalyst was removed by suction filtration over Celite and the filtrate was concentrated to give a colorless oil (318 mg, 100% crude yield). Crude product 120 was used for next step without further purification. m/z (ESI) 366 [C19H31N3O4+H]+.

후처리

  1. customCatalyst was removed by suction filtration over Celite
  2. concentrationthe filtrate was concentrated
  3. customto give a colorless oil (318 mg, 100% crude yield)
  4. customCrude product 120 was used for next step without further purification

출처 및 근거

ORD 기록
ord-de88cd79eb1942efb1c46d535ade65c8
출처 데이터셋
uspto-grants-2011_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07875619B2

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