Acetic Acid → HCID 59514331, 화합물
반응식
[CH2:1]([O:3][C:4]([C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[CH:16]=[CH2:17])[CH:9]=[CH:8][CH:7]=1)=[O:5])[CH3:2].C(O)(=O)C>CCO.[Pd]>[CH2:1]([O:3][C:4]([C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][C:14]=2[CH2:16][CH3:17])[CH:9]=[CH:8][CH:7]=1)=[O:5])[CH3:2]참가 물질
5
실험 절차
A solution of 8-vinyl-naphthalene-1-carboxylic acid ethyl ester (1.1 g) in EtOH (25 ml) was treated with acetic acid (1 ml) and Pd/C (270 mg; 10%) and hydrogenated at normal pressure overnight. The catalyst was filtered off. The filtrate was concentrated. The crude product was isolated by chromatography (silica gel; gradient: cyclohexane→cyclohexane/EtOAc 3:2) to give 8-ethyl-naphthalene-1-carboxylic acid ethyl ester (1.05 g) as colorless liquid. MS (ISP): 229.3 ((M+H)+.).
후처리
- customhydrogenated at normal pressure overnight
- filtrationThe catalyst was filtered off
- concentrationThe filtrate was concentrated
- customThe crude product was isolated by chromatography (silica gel; gradient: cyclohexane→cyclohexane/EtOAc 3:2)
출처 및 근거
- ORD 기록
- ord-09d58e4aac8e4058b0b782dec3d869e6
- 출처 데이터셋
- uspto-grants-2011_01
- 특허 번호
- US07875645B2
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