Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Iodine → HCID 66851890, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | 3,3-Dimethylbutanal | HCID 76335 | — |
| 반응물 | Potassium thiocyanate | HCID 516872 | — |
| 반응물 | 1-(Aminomethyl)cyclopentan-1-ol | HCID 13051202 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | HCID 66851890 | HCID 66851890 | 73.3% |
반응 단계
A mixture of 1-(aminomethyl)cyclopentanol (prepared from cyclopentanone as described in WO 2006/100208) (3.5 g, 30 mmol), 3,3-dimethylbutanal (3.4 g, 33 mmol), 4 Å molecular sieves (4 g, 8-12 mesh beads), potassium thiocyanate (3.9 g, 40 mmol) and iodine (7.7 g, 30 mmol) in acetonitrile (50 mL) were processed as described in Example 18A to provide the title compound (5.6 g, 22 mmol, 72% yield). MS (DCI/NH3) m/z 255 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07875640B2 |
| 출처 데이터셋 | uspto-grants-2011_01 |
| ORD ID | ord-76dc9757d17c48a180e137e0db6aac40 |
| 출처 메모 | uspto-grants-2011_01 |